Publications

2026

• Al-Jeffery A, Zeng F, Sophocleous A, Marino S, Ponzetti M, Capulli M, Paul A, Plevin R, Fowles ACM, Mackay SP, Rucci N, Idris AI. Differential effects of a first-in-class IKKα inhibitor on trabecular and cortical bone in a human prostate cancer xenograft model. Calcif Tissue Int 117:122;2026. doi: 10.1007/s00223-026-01558-y
• Maurizi A, Pucci E, Patrizii P, Silvestri L, Rucci N*, Capulli M. Generation of a P4hbY393C mouse model of cole-carpenter syndrome and therapeutic proof-of-concept. Life Sci 402:124593;2026. doi: 10.1016/j.lfs.2026.124593 *Corresponding author.
• Bevacqua E, Granata V, Panetta D, Longo E, Prašek M, Sanchez PJ, Violi F, Giacchi L, Bertola L, Tromba G, Santillo M, Rucci N, Recordati C, Mazziotti G, Morenghi E, Menale C, Sobacchi C. DPP3 deficiency impacts bone quality and sensitizes to metabolic alterations. Bone 210:117951;2026. doi: 10.1016/j.bone.2026.117951
• Giacchi L, Ucci A, Zelli V, Compagnoni C, Pucci E, Tessitore A, Ponzetti M, Rucci N. Effect of osteoblast-derived extracellular vesicles on osteosarcoma cells' transcriptional profile: role of shuttled miRNAs. Biomedicines 14:1039;2026. doi: 10.3390/biomedicines14051039
• Ligotti ME, Scalia E, Scilabra SD, Pinto ML, Gallo A, Vazzana R, Cuscino N, Re OL, Pipia C, Amico G, Lopa S, Colombini A, Ippolito V, Maurizi A, Rucci N, Agnese V, Conaldi PG, Moretti M, Miceli V, Bulati M. Priming-Dependent Modulation of Secretome in placenta- and adipose-derived mesenchymal stromal/stem cells: toward cell-free immunoregenerative therapies for osteochondral and degenerative joint diseases. Stem Cell Rev Rep 22:2453-73;2026. doi: 10.1007/s12015-026-11122-8
• Giacchi L, Ucci A, Pucci E, Lancia L, Pulcini F, Delle Monache S, Rucci N*, Ponzetti M. Extracellular vesicles from osteotropic triple-negative breast cancer cells transfer miRNAs to bone cells reducing collagen expression and bone matrix mineralisation. Pharmaceutics 18:317;2026. doi: 10.3390/pharmaceutics18030317 *Corresponding author.
• Giacchi L, Pucci E, Rucci N. From bench to bedside: advancements in precision oncology and drug discovery for osteosarcoma. Cancers (Basel). 18:561;2026. doi: 10.3390/cancers18040561

2025

• Ucci A, Giacchi L, Cufaro MC, Puri C, Ciocca M, Di Ferdinando F, Del Boccio P, Cappariello A, Rucci N. Human osteosarcoma cell secretome impairs neonatal mouse calvarial osteogenic cells functions and modifies the nanoparticles-derived protein profile. Life Sci 379:123837;2025. doi: 10.1016/j.lfs.2025.123837
• Di Nicola N, Giacchi L, Vandone M, Crucianelli M, Guidoni L, Colombo V, Rucci N, Lazzarini A. Targeted delivery of lidocaine in breast cancer cells via zeolitic imidazolate framework-8 nanoparticles. Chemphyschem 26:e2401128;2025. doi: 10.1002/cphc.202401128

2024

• Ucci A, Giacchi L, Rucci N. Primary bone tumors and breast cancer-induced bone metastases: in vivo animal models and new alternative approaches. Biomedicines 12:2451;2024. doi: 10.3390/biomedicines12112451
• Schiavone ML, Crisafulli L, Camisaschi C, De Simone G, Liberati FR, Palagano E, Rucci N, Ficara F, Sobacchi C. Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation. Stem Cell Res Ther 15:203;2024. doi: 10.1186/s13287-024-03803-3
• Puri C, Dannenberg C, Ucci A, Ponzetti M, Pucci E, Silvestri L, Lau P, Frings-Meuthen P, Heer M, Rucci N, Teti A, Maurizi A. Pre-proenkephalin 1 is Downregulated Under Unloading and is Involved in Osteoblast Biology. Calcif Tissue Int 114:524-34;2024 doi: 10.1007/s00223-024-01199-z

2023

• Ponzetti M, Rucci N, Falone S. RNA methylation and cellular response to oxidative stress-promoting anticancer agents. Cell Cycle 22:870-905;2023. doi: 10.1080/15384101.2023.2165632
• Cappariello A, Muraca M, Teti A, Rucci N. Circulating extracellular vesicles express receptor activator of Nuclear Factor κB Ligand and other molecules informative of the bone metabolic status of mouse models of experimentally induced osteoporosis. Calcif Tissue Int 112:74-91;2023. doi: 10.1007/s00223-022-01032-5

2022

• Ponzetti M, Ucci A, Puri C, Giacchi L, Flati I, Capece D, Zazzeroni F, Cappariello A, Rucci N*, Falone S. Effects of osteoblast-derived extracellular vesicles on aggressiveness, redox status and mitochondrial bioenergetics of MNNG/HOS osteosarcoma cells. Front Oncol 12:983254;2022. doi: 10.3389/fonc.2022.983254 *Correspinding author.
• Giordano A, Rucci N, Falone S. Editorial: Extracellular vesicles as modulators of cancer cell adaptive responses linked to therapy resistance. Front Oncol. 12:1101103;2022. doi: 10.3389/fonc.2022.1101103
• Ponzetti M, Chinna Rao Devarapu G, Rucci N, Carlone A, Saggiomo V. HistoEnder: A 3D printer-based histological slide autostainer that retains 3D printer functions. HardwareX. 12:e00370;2022. doi: 10.1016/j.ohx.2022.e00370
• Ucci A, Rucci N, Ponzetti M. Liquid biopsies in primary and secondary bone cancers. Cancer Drug Resist 21:541-59;2022. doi: 10.20517/cdr.2022.17
• Faraldi M, Sansoni V, Perego S, Gomarasca M, Gerosa L, Ponzetti M, Rucci N, Banfi G, Lombardi G. Acute changes in free and extracellular vesicle-associated circulating miRNAs and myokine profile in professional sky-runners during the Gran Sasso d'Italia vertical run. Front Mol Biosci 9:915080;2022. doi: 10.3389/fmolb.2022.915080
• Ponzetti M, Ucci A, Maurizi A, Giacchi L, Teti A, Rucci N. Lipocalin 2 influences bone and muscle phenotype in the MDX mouse model of Duchenne muscular dystrophy. Int J Mol Sci 23:958;2022. doi: 10.3390/ijms23020958
• Ponzetti M, Aielli F, Ucci A, Cappariello A, Lombardi G, Teti A, Rucci N. Lipocalin 2 increases after high-intensity exercise in humans and influences muscle gene expression and differentiation in mice. J Cell Physiol 237:551-565;2022. doi: 10.1002/jcp.30501

2021

• Cappariello A, Rucci N. Extracellular vesicles in bone tumors: how to seed in the surroundings molecular information for malignant transformation and progression. Front Oncol 11:722922;2021. doi: 10.3389/fonc.2021.722922
• Di Benedetto P, Ruscitti P, Berardicurti O, Panzera N, Grazia N, Di Vito Nolfi M, Di Francesco B, Navarini L, Maurizi A, Rucci N, Teti AM, Zazzeroni F, Guggino G, Ciccia F, Dolo V, Alesse E, Cipriani P, Giacomelli R. Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis. Arthritis Res Ther 23:213;2021. doi: 10.1186/s13075-021-02587-8
• Ucci A, Cappariello A, Ponzetti M, Tennant F, Loftus AEP, Shefferd K, Maurizi A, Delle Monache S, Teti A, Rucci N. Anti-osteoblastogenic, pro-inflammatory and pro-angiogenic effect of extracellular vesicles isolated from the human osteosarcoma cell line MNNG/HOS. Bone 153:116130;2021. doi: 10.1016/j.bone.2021.116130
• Ponzetti M, Rucci N. Osteoblast differentiation and signaling: established concepts and emerging topics. Int J Mol Sci 22:6651;2021. doi: 10.3390/ijms22136651
• Maurizi A, Ponzetti M, Gautvik KM, Reppe S, Teti A, Rucci N. Lipocalin 2 serum levels correlate with age and bone turnover biomarkers in healthy subjects but not in postmenopausal osteoporotic women. Bone Rep 14:101059;2021. doi: 10.1016/j.bonr.2021.101059
• Maurizi A, Ponzetti M, Rucci N. How the “seed” prepares the “soil”: the bone/bone marrow pre-metastatic niche. J Cancer Metastasis Treat 7:35;2021. doi: 10.20517/2394-4722.2021.74
• Norwood I, Szondi D, Ciocca M, Coudert A, Cohen-Solal M, Rucci N, Teti A, Maurizi A. Transcriptomic and bioinformatic analysis of Clcn7-dependent Autosomal Dominant Osteopetrosis type 2. Preclinical and clinical implications. Bone 144:115828;2021. doi: 10.1016/j.bone.2020.115828

2020

• Di Giminiani R, Rucci N, Capuano L, Ponzetti M, Aielli F, Tihanyi J. Individualized whole-body vibration: neuromuscular, biochemical, muscle damage and inflammatory acute responses. Dose Response 18:1559325820931262;2020. doi: 10.1177/1559325820931262
• Ponzetti M, Rucci N. Switching homes: how cancer moves to bone. Int J Mol Sci 21:4124;2020. doi: 10.3390/ijms21114124
• Loftus A, Cappariello A, George C, Ucci A, Shefferd K, Green A, Paone R, Ponzetti M, Delle Monache S, Muraca M, Teti A, Rucci N. Extracellular vesicles from osteotropic breast cancer cells affect bone resident cells. J Bone Miner Res 35:396-412;2020. doi: 10.1002/jbmr.3891

2019

• Cappariello A, Rucci N. Tumour-derived extracellular vesicles (EVs): a dangerous “message in a bottle” for bone. Int J Mol Sci 20:4805;2019. doi: 10.3390/ijms20194805
• Capulli M, Hristova D, Valbret Z, Carys K, Arjan R, Maurizi A, Masedu F, Cappariello A, Rucci N, Teti A. Notch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry. Br J Cancer 121:157-71;2019. doi: 10.1038/s41416-019-0501-y
• Maurizi A, Capulli M, Curle A, Patel R, Ucci A, Côrtes JA, Oxford H, Lamandé SR, Bateman JF, Rucci N, Teti A. Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications. Bone Res 7:17;2019. doi: 10.1038/s41413-019-0055-x
• Marino S, de Ridder D, Bishop RT, Renema N, Ponzetti M, Sophocleous A, Capulli M, Aljeffery A, Carrasco G, Gens MD, Khogeer A, Ralston SH, Gertsch J, Lamoureux F, Heymann D, Rucci N, Idris AI. Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice. EBioMedicine 44:452-66;2019. doi: 10.1016/j.ebiom.2019.05.048
• Ponzetti M, Rucci N. Updates on osteoimmunology: what is new on the crosstalk between bone and immune system. Front Endocrinol 10:236;2019. doi: 10.3389/fendo.2019.00236
• Rucci N, Zallone A, Teti A. Isolation and generation of osteoclasts. Methods Mol Biol 1914:3-19;2019. doi: 10.1007/978-1-4939-8997-3_1
• Aielli F, Ponzetti M, Rucci N. Bone metastasis pain, from the bench to the bedside. Int J Mol Sci 20:280;2019. doi: 10.3390/ijms20020280
• Sartoretto S, Gemini-Piperni S, da Silva RA, Calasans MD, Rucci N, Pires Dos Santos TM, Lima IBC, Rossi AM, Alves G, Granjeiro JM, Teti A, Zambuzzi WF. Apoptosis-associated speck-like protein containing a caspase-1 recruitment domain (ASC) contributes to osteoblast differentiation and osteogenesis. J Cell Physiol 234:4140-53;2019. doi: 10.1002/jcp.27226

2018

• Maurizi A, Rucci N. The osteoclast in bone metastasis: player and target. Cancers 10:218;2018. doi: 10.3390/cancers10070218
• Marino S, Bishop RT, Capulli M, Sophocleous A, Logan JG, Mollat P, Mognetti B, Ventura L, Sims AH, Rucci N, Ralston SH, Idris AI. Regulation of breast cancer induced bone disease by cancer specific IKKβ. Oncotarget 9:16134-16148;2018. doi: 10.18632/oncotarget.24743
• Maurizi A, Capulli M, Patel R, Curle A, Rucci N, Teti A. RNA interference therapy for autosomal dominant osteopetrosis type 2. Towards the preclinical development. Bone 110:243-354;2018. doi: 10.1016/j.bone.2018.02.031
• Capulli M, Ponzetti M, Maurizi A, Gemini-Piperni S, Berger T, Mak TW, Teti A, Rucci N. A complex role for Lipocalin 2 in bone metabolism: global ablation in mice induces osteopenia caused by an altered energy metabolism. J Bone Miner Res 33:1141-53;2018. doi: 10.1002/jbmr.3406
• Peramuhendige P, Marino S, Bishop RT, de Ridder D, Khogeer A, Baldini I, Capulli M, Rucci N, Idris AI. TRAF2 in osteotropic breast cancer cells enhances skeletal tumour growth and promotes osteolysis. Sci Rep 8:39;2018. doi: 10.1038/s41598-017-18327-5
• Rucci N, Teti A. Osteomimicry: how the seed grows in the soil. Calcif Tissue Int 102:131-40;2018. doi: 10.1007/s00223-017-0365-1
• Cappariello A, Loftus A, Muraca M, Maurizi A, Rucci N, Teti A. Osteoblast-derived extracellular vesicles are biological tools for the delivery of active molecules to bone. J Bone Miner Res 33:517-33;2018. doi: 10.1002/jbmr.3332

2017

• Di Pompo G, Lemma S, Canti L, Rucci N, Ponzetti M, Errani C, Donati DM, Russell S, Gillies R, Chano T, Baldini N, Avnet S. Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma. Oncotarget 8:54478-496;2017. doi: 10.18632/oncotarget.17091
• Ponzetti M, Capulli M, Angelucci A, Ventura L, Monache SD, Mercurio C, Calgani A, Sanità P, Teti A, Rucci N. Non-conventional role of haemoglobin beta in breast malignancy. Br J Cancer 117:994-1006;2017. doi: 10.1038/bjc.2017.247

2016

• Wright LE, Ottewell PD, Rucci N, Peyruchaud O, Pagnotti GM, Chiechi A, Buijs JT, Sterling JA. Murine models of breast cancer bone metastasis. BoneKey Rep 5:804;2016. doi: 10.1038/bonekey.2016.31
• Veeriah V, Zanniti A, Paone R, Chatterjee S, Rucci N, Teti A, Capulli M. Interleukin-1β, lipocalin 2 and nitric oxide synthase 2 are mechano-responsive mediators of mouse and human endothelial cell-osteoblast crosstalk. Sci Rep 6:29880;2016. doi: 10.1038/srep29880
• Cappariello A, Ponzetti M, Rucci N. The “soft” side of the bone: unveiling its endocrine functions. Horm Mol Biol Clin Investig 28:5-20;2016. doi: 10.1038/srep29880
• Rucci N, Teti A. The "love-hate" relationship between osteoclasts and bone matrix. Matrix Biol 52-54:176-90;2016. doi: 10.1016/j.matbio.2016.02.009
• Thaler R, Maurizi A, Roschger P, Sturmlechner I, Khani F, Spitzer S, Rumpler M, Zwerina J, Karlic H, Dudakovic A, Klaushofer K, Teti A, Rucci N, Varga F, van Wijnen AJ. Anabolic and antiresorptive modulation of bone homeostasis by the epigenetic modulator sulforaphane, a naturally occurring isothiocyanate. J Biol Chem 291:6754-71;2016. doi: 10.1074/jbc.M115.678235

2015

• Capulli M, Maurizi A, Ventura L, Rucci N, Teti A. Effective small interfering RNA therapy to treat CLCN7-dependent Autosomal Dominant Osteopetrosis Type 2. Mol Ther Nucleic Acids. 4:e248;2015. doi: 10.1038/mtna.2015.21
• Cappariello A, Paone R, Maurizi A, Capulli M, Rucci N, Muraca M, Teti A. Biotechnological approach for systemic delivery of membrane Receptor Activator of NF-kB Ligand (RANKL) active domain into the circulation. Biomaterials 46:58-69;2015. doi: 10.1016/j.biomaterials.2014.12.033
• Rucci N*, Capulli M, Olstad OK, Önnerfjord P, Tillgren V, Gautvik KM, Heinegård D, Teti A. The α2β1 binding domain of chondroadherin inhibits breast cancer-induced bone metastases and impairs primary tumour growth: a preclinical study. Cancer Lett 358:67-75;2015. doi: 10.1016/j.canlet.2014.12.032 *Corresponding author.
• Rucci N, Capulli M, Piperni SG, Cappariello A, Lau P, Frings-Meuthen P, Heer M, Teti A. Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis. J Bone Miner Res 30:357-368;2015. doi: 10.1002/jbmr.2341

2014

• Rucci N, Sanità P, Delle Monache S, Alesse E, Angelucci A. Molecular pathogenesis of bone metastases in breast cancer: proven and emerging therapeutic targets. World J Clin Oncol 5:335-47;2014. doi: 10.5306/wjco.v5.i3.335
• Rucci N, Angelucci A. Prostate cancer and bone: the elective affinities. Biomed Res Int 2014:167035; 2014. doi: 10.1155/2014/167035
• Capulli M, Paone R, Rucci N. Osteoblast and osteocyte: games without frontiers. Arch Biochem Biophys 561:3-12;2014. doi: 10.1016/j.abb.2014.05.003
• Capulli M, Olstad OK, Önnerfjord P, Tillgren V, Muraca M, Gautvik KM, Heinegård D, Rucci N+, Teti A+. The C-terminal domain of chondroadherin: a new regulator of osteoclast motility counteracting bone loss. J Bone Miner Res. 29:1833-1846;2014. doi: 10.1002/jbmr.2206 +Equal contributors.
• Del Fattore A, Cappariello A, Capulli M, Rucci N, Muraca M, De Benedetti F, Teti A. An experimental therapy to improve skeletal growth and prevent bone loss in a mouse model overexpressing IL-6. Osteoporos Int 25:681-92;2014. doi: 10.1007/s00198-013-2479-2

2013

• Rucci N, Capulli M, Ventura L, Angelucci A, Peruzzi B, Tillgren V Muraca M, Heinegård D, Teti A. Proline/arginine-rich end leucine-rich repeat protein N-terminus is a novel osteoclast antagonist that counteracts bone loss. J Bone Miner Res 28:1912-24;2013. doi: 10.1002/jbmr.1951

2012

• Capulli M, Angelucci A, Driouch K, Garcia T, Clement-Lacroix P, Martella F, Ventura L, Bologna M, Flamini S, Moreschini O, Lidereau R, Ricevuto E, Muraca M, Teti A, Rucci N. Increased expression of a set of genes enriched in oxygen binding function discloses a predisposition of breast cancer bone metastases to generate metastasis spread in multiple organs. J Bone Miner Res 27:2387-98;2012. doi: 10.1002/jbmr.1686
• Rucci N, Takayanagi H. Editorial: bone and immune system cross-talk. Inflamm Allergy Drug Targets. 11:169;2012. doi: 10.2174/187152812800392779
• Cardone RA, Greco MR, Capulli M, Weinman EJ, Busco G, Bellizzi A, Casavola V, Antelmi E, Ambruosi B, Dell'Aquila ME, Paradiso A, Teti A, Rucci N, Reshkin SJ. NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains. Mol Biol Cell 23:2028-40;2012. doi: 10.1091/mbc.E11-11-0911
• Peruzzi B, Cappariello A, Del Fattore A, Rucci N, De Benedetti F, Teti A. c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling. Nat Commun 3:630;2012. doi: 10.1038/ncomms1651
• Del Fattore A, Teti A, Rucci N. Bone cells and the mechanisms of bone remodelling. Front Biosci (Elite Ed.) 4:2302-21;2012. doi: 10.2741/e543

2011

• Rucci N, Sanità P, Angelucci A. Role of metalloproteinases in metastatic niche. Curr Mol Med 11:609-22;2011. doi: 10.2174/156652411797536705
• Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A. Mechanisms inducing low bone density in Duchenne muscular dystrophy in mice and humans. J Bone Miner Res 26:1891-903;2011. doi: 10.1002/jbmr.410

2010

• Del Fattore A, Capannolo M, Rucci N. Bone and bone marrow: the same organ. Arch Biochem Biophys 503:28-34;2010. doi: 10.1016/j.abb.2010.07.020
• Rucci N, Millimaggi D, Mari M, Del Fattore A, Bologna M, Teti A, Angelucci A, Dolo V. Receptor activator of NFkB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147. Cancer Res 70:6150-60;2010. doi: 10.1158/0008-5472.CAN-09-2758
• Salerno M, Cenni E, Fotia C, Avnet S, Granchi D, Castelli F, Micieli D, Pignatello R, Capulli M, Rucci N, Angelucci A, Del Fattore A, Teti A, Zini N, Giunti A, Baldini N. Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases. Curr Cancer Drug Targets. 10:649-59;2010. doi: 10.2174/156800910793605767
• Rucci N, Teti A. Osteomimicry: how tumor cells try to deceive the bone. Front Biosci (Schol Ed.) 2:907-15;2010. doi: 10.2741/s110
• Teti A, Rucci N. The unexpected links between bone and immune system. Medicographia 32:341-48;2010.

2009

• Rucci N, Rufo A, Alamanou M, Capulli M, Del Fattore A, Åhrman E, Capece D, Iansante V, Zazzeroni F, Alesse E, Heinegård D, Teti A. The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis. J Cell Biol 187:669-83;2009. doi: 10.1083/jcb.200906014
• Capulli M, Rufo A, Teti A, Rucci N. Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a “mechanoresponsive ostoblast gene signature”. J Cell Biochem 107:240-52;2009. doi: 10.1002/jcb.22120
• Taddei ML, Parri M, Angelucci A, Onnis B, Bianchini F, Giannoni E, Raugei G, Calorini L, Rucci N, Teti A, Bologna M, Chiarugi P. Kinase-dependent and independent role of EphA2 in the regulation of prostate cancer invasion and metastasis. Am J Pathology 174:1492-1503;2009. doi: 10.2353/ajpath.2009.080473
• Pierroz DD, Rufo A, Bianchi EN, Glatt V, Capulli M, Rucci N, Cavat F, Rizzoli R, Teti A, Bouxsein ML, Ferrari SL. Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. J Bone Miner Res 24:775-84;2009. doi: 10.1359/jbmr.081237

2008

• Landemaine T, Jackson A, Bellahcène A, Rucci N, Sin S, Abad SM, Sierra A, Boudinet A, Guinebretière JM, Ricevuto E, Noguès C, Briffod M, Bièche I, Cherel P, Garcia T, Castronovo V, Teti A, Lidereau R, Driouch K. A six-gene signature predicting breast cancer lung metastasis. Cancer Res 68:6092-99;2008. doi: 10.1158/0008-5472.CAN-08-0436
• Rucci N, Susa M, Teti A. inhibition of protein kinase c-Src as a therapeutic approach for cancer and bone metastases. Anticancer Agents Med Chem 8:342-349;2008. doi: 10.2174/187152008783961905
• Del Fattore A, Teti A, Rucci N. Osteoclast receptors and signaling. Arch Biochem Biophys. 473:147-60;2008. doi: 10.1016/j.abb.2008.01.011
• Rucci N. Molecular biology of bone remodelling. Clin Cases Miner Bone Metab 5:49-56;2008. PMCID: PMC2781193
• Del Fattore A, Fornari R, Van Wesenbeeck L, de Freitas F, Timmermans JP, Peruzzi B, Cappariello A, Rucci N, Spera G, Helfrich MH, Van Hul W, Migliaccio S, Teti A. A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts. J Bone Miner Res 23:380-91;2008. doi: 10.1359/jbmr.071107

2007

• Nissen-Meyer LS, Jemtland R, Gautvik VT, Pedersen ME, Paro R, Fortunati D, Pierroz DD, Stadelmann VA, Reppe S, Reinholt FP, Del Fattore A, Rucci N, Teti A, Ferrari S, Gautvik KM. Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice. J Cell Sci 120:2785-95;2007. doi: 10.1242/jcs.003855
• Rucci N, Rufo A, Alamanou M, Teti A. Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratio. J Cell Biochem 100:464-73;2007. doi: 10.1002/jcb.21059

2006

• De Benedetti F, Rucci N, Del Fattore A, Peruzzi B, Paro R, Longo M, Vivarelli M, Muratori F, Berni S, Ballanti P, Ferrari S, Teti A. Impaired skeletal development in interleukin-6 transgenic mice. A model for the impact of chronic inflammation on the growing skeletal system. Arthritis Rheum 54:3551-63;2006. doi: 10.1002/art.22175
• Rucci N, Recchia I, Angelucci A, Alamanou M, Del Fattore A, Fortunati D, Susa M, Fabbro D, Bologna M, Teti A. Inhibition of protein kinase c-Src reduces breast cancer metastases and increases survival in mice. J Pharmacol Exp Ther 318:161-72;2006. doi: 10.1124/jpet.106.102004
• Angelucci A, Gravina GL, Rucci N, Millimaggi D, Festuccia C, Muzi P, Teti A, Vicentini C, Bologna M. Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice. Endocr Relat Cancer 13:197-210;2006. doi: 10.1677/erc.1.01100
• Millimaggi D, Festuccia C, Angelucci A, D’Ascenzo S, Rucci N, Flati S, Bologna M, Teti A, Pavan A, Dolo E. Osteoblast-conditioned media stimulate membrane shedding in prostate cancer cells. Int J Oncol 28:909-14;2006. PMID: 16525640.
• Del Fattore A, Peruzzi B, Rucci N, Recchia I, Cappariello A, Longo M, Fortunati D, Ballanti P, Iacobini M, Luciani M, Devito R, Pinto R, Caniglia M, Lanino E, Messina C, Cesaro S, Letizia C, Bianchini G, Fryssira H, Grabowski P, Shaw N, Bishop N, Hughes D, Kapur RP, Datta HK, Taranta A, Fornari R, Migliaccio S, Teti A. Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: implications for diagnosis and treatment. J Med Genet 43:315-25;2006. doi: 10.1136/jmg.2005.036673

2005

• Rucci N, Di Giacinto C, Orrù L, Millimaggi D, Baron R, Teti A. A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and chinese hamster ovary (CHO) cells. J Cell Sci 118:3263-75;2005.
• Margheri F, D’Alessio S, Serratì S, Pucci M, Annunziato F, Cosmi L, Liotta F, Angeli R, Angelucci A, Gravina GL, Rucci N, Bologna M, Teti A, Monia B, Fibbi G, Del Rosso M. Effect of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases. Gene Ther 12:702-14;2005. doi: 10.1038/sj.gt.3302456

2004

• Angelucci A, Gravina GL, Rucci N, Festuccia C, Muzi P, Vicentini C, Teti A, Bologna M. Evaluation of metastatic potential in prostate carcinoma: an in vivo model. Int J Oncol 25:1713-20;2004. PMID: 15547709.
• Tacconelli A, Farina AR, Cappabianca L, DeSantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR. TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. Cancer Cell 6:347-60;2004. doi: 10.1016/j.ccr.2004.09.011
• D'Abrizio P, Baldini E, Russo PF, Biordi L, Graziano FM, Rucci N, Properzi G, Francavilla S, Ulisse S. Ontogenesis and cell specific localization of Fas ligand expression in the rat testis. Int J Androl 27:304-10;2004. doi: 10.1111/j.1365-2605.2004.00483
• Taranta A, Fortunati D, Longo M, Rucci N, Iacomino E, Alberti F, Facciuto E, Migliaccio S, Bardella MT, Dubini A, Saraifoger S, Teti A, Bianchi ML. Imbalance of osteoclastogenesis-regulating factors in celiac disease. J Bone Miner Res 19:1112-1121;2004. doi: 10.1359/JBMR.040319
• Rucci N, Ricevuto E, Ficorella C, Longo M, Perez M, Di Giacinto C, Funari A, Teti A, Migliaccio S. In vivo bone metastases, osteoclastogenic ability and phenotypic characterization of human breast cancer cells. Bone 34:697-709;2004. doi: 10.1016/j.bone.2003.07.012
• Recchia I, Rucci N, Funari A, Migliaccio S, Taranta A, Longo M, Kneissel M, Susa M, Fabbro D, Teti A. Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]-pyrimidines induces osteoclast apoptosis in vivo and in vitro. Involvement of ERK1/2 pathway. Bone 34:65-79;2004. doi: 10.1016/j.bone.2003.06.004

2003

• Crescenzi A, Graziano MF, Carosa E, Papini E, Rucci N, Nardi F, Trimboli P, Calvanese A, Jannini EA, D'Armiento M. Localization and expression of thyroid hormone receptors normal and neoplastic human thyroid. J Endocrinol Invest 26:1008-12;2003. doi: 10.1007/BF03348200
• Recchia I, Rucci N, Festuccia C, Bologna M, MacKay AR, Migliaccio S, Longo M, Susa M, Fabbro D, Teti A. Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro. Eur J Cancer 39:1927-35;2003. doi: 10.1016/s0959-8049(03)00394-0

2002

• Basciani S, Mariani S, Arizzi M, Ulisse S, Rucci N, Jannini EA, Della Rocca C, Manicone A, Carani C, Spera G, Gnessi L. Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease. J Clin Endocrinol Metab 87:2310-9;2002. doi: 10.1210/jcem.87.5.8476
• Rucci N, Migliaccio S, Zani BM, Taranta A, Teti A. Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV). J Cell Biochem 85:167-79;2002. PMID: 11891860.

2000

• Ulisse S, Cinque B, Silvano G, Rucci N, Biordi L, Cifone MG, D'Armiento M. Erk-dependent cytosolic phospholipase A2 activity is induced by CD95 ligand cross-linking in the mouse derived Sertoli cell line TM4 and is required to trigger apoptosis in CD95 bearing cells. Cell Death Differ 7:916-24;2000. doi: 10.1038/sj.cdd.4400716
• Jannini EA, Crescenzi A, Rucci N, Screponi E, Carosa E, de Matteis A, Macchia E, d'Amati G, D'Armiento M. Ontogenetic pattern of thyroid hormone receptor expression in the human testis. J Clin Endocrinol Metab 85:3453-7;2000. doi: 10.1210/jcem.85.9.6803
• Francavilla S, D'Abrizio P, Rucci N, Silvano G, Properzi G, Straface E, Cordeschi G, Necozione S, Gnessi L, Arizzi M, Ulisse S. Fas and Fas ligand expression in fetal and adult human testis with normal or deranged spermatogenesis. J Clin Endocrinol Metab 85:2692-700;2000. doi: 10.1210/jcem.85.8.6723

1999

• Jannini EA, Carosa E, Rucci N, Screponi E, D'Armiento M. Ontogeny and regulation of variant thyroid hormone receptor isoforms in developing rat testis. J Endocrinol Invest 22:843-8;1999. doi: 10.1007/BF03343656
• Cecconi S, Rucci N, Scaldaferri ML, Masciulli MP, Rossi G, Moretti C, D'Armiento M, Ulisse S. Thyroid hormone effects on mouse oocyte maturation and granulosa cell aromatase activity. Endocrinology. 140:1783-8;1999. doi: 10.1210/endo.140.4.6635

1998

• Ulisse S, Rucci N, Piersanti D, Carosa E, Graziano FM, Pavan A, Ceddia P, Arizzi M, Muzi P, Cironi L, Gnessi L, D'Armiento M, Jannini EA. Regulation by thyroid hormone of the expression of basement membrane components in rat prepubertal Sertoli cells. Endocrinology. 139:741-7;1998. doi: 10.1210/endo.139.2.5732